TB-500 (10 Vial Box)

Compliance & Disclaimer

• For Research Use Only
• Not FDA or EMA approved for clinical application
• Evidence is limited to preclinical studies; safety and efficacy in humans remain unestablished.

TB-500 is a synthetic peptide fragment derived from thymosin beta-4 (Tβ4), a naturally occurring 43-amino-acid protein widely distributed in mammalian tissues. Tβ4 plays a critical role in cytoskeletal regulation, wound healing, and tissue remodeling. TB-500 retains the actin-binding domain of Tβ4, enabling investigation into its effects on cell migration, angiogenesis, and tissue repair under experimental conditions. [peptidesystems.com], [biolongevitylabs.com]

Mechanistically, TB-500 functions as a G-actin sequestering molecule, maintaining an intracellular pool of actin monomers for rapid polymerization during cellular migration and tissue regeneration. This property facilitates processes such as lamellipodia formation, focal adhesion turnover, and endothelial tube formation, which are essential for wound closure and vascularization. Research also indicates TB-500 upregulates angiogenic factors including VEGF (vascular endothelial growth factor) and modulates inflammatory signaling pathways such as NF-κB, contributing to balanced immune responses during tissue repair. [peptidesystems.com] [peptidesystems.com], [biolongevitylabs.com]

Preclinical studies have explored TB-500’s role in soft tissue regeneration, including skeletal muscle, tendon, ligament, and cardiac tissue models. Findings suggest accelerated wound healing, enhanced collagen deposition, and improved tensile strength in controlled experimental settings. Additional investigations highlight its potential to influence angiogenesis, oxidative stress regulation, and stem cell mobilization, positioning TB-500 as a subject of interest in regenerative biology and cytoskeletal research. [peptideini...iative.com], [lotilabs.com] [peptideskingdom.com]

Key Peer-Reviewed References

1. Malinda K.M. et al. Thymosin β4 accelerates wound healing. Journal of Investigative Dermatology. 2004; DOI:10.1111/j.0022-202X.2004.23204.x [peptideini...iative.com]
2. Goldstein A.L. et al. Thymosin β4 promotes cardiac protection and repair. Annals of the NY Academy of Sciences. 2012; DOI:10.1111/j.1749-6632.2012.06762.x [peptideini...iative.com]
3. Anderson J. TB-500 (Thymosin Beta-4): Mechanisms and Research. Peptide Systems. 2024. Link [peptidesystems.com]
4. Ky H. Le, MD. TB-500 Peptide Research: The Science Behind Thymosin Beta-4. BioLongevity Labs. 2025. Link [biolongevitylabs.com]
5. Maple K., Monis A. TB-500 Medical Evidence. Medical Anti-Aging White Paper. 2024. Link [medicalantiaging.com]