SLU-PP-332

SLU-PP-332: Mechanistic Overview and Research Context

SLU-PP-332 is a synthetic small-molecule agonist that targets the estrogen-related receptor (ERR) family, comprising ERRα, ERRβ, and ERRγ. These orphan nuclear receptors are key transcriptional regulators of cellular energy metabolism and mitochondrial biogenesis. Unlike classical estrogen receptors, ERRs do not bind endogenous estrogens; instead, they modulate gene networks involved in oxidative phosphorylation, fatty acid oxidation, and thermogenic pathways. [biolongevitylabs.com], [link.springer.com], [synapse.patsnap.com]

By activating ERRs—particularly ERRα—SLU-PP-332 promotes recruitment of coactivators such as PGC-1α, a master regulator of mitochondrial biogenesis. This interaction drives transcriptional programs that mimic exercise-induced metabolic adaptations, including enhanced oxidative metabolism, increased mitochondrial respiratory capacity, and improved fatty acid utilization. [ujpronline.com], [biolongevitylabs.com], [fluxlabsusa.com]

Preclinical Evidence

In rodent models of obesity and metabolic syndrome, SLU-PP-332 administration has been associated with:

• Increased whole-body energy expenditure and fatty acid oxidation
• Upregulation of mitochondrial biogenesis and oxidative phosphorylation genes
• Improved insulin sensitivity and reduced adiposity
• Activation of an acute aerobic exercise-like transcriptional response in skeletal muscle. [profiles.wustl.edu], [combatresearch.is], [fluxlabsusa.com]

These findings position SLU-PP-332 as a research tool for studying exercise-mimetic pathways and mitochondrial function. Importantly, all reported effects are based on preclinical studies, and the compound is not approved for human use.

Research Applications

Current investigations focus on SLU-PP-332 for:

• Modeling exercise-induced metabolic adaptations in vitro and in vivo
• Exploring ERR-mediated transcriptional networks in energy metabolism
• Studying mitochondrial biogenesis and oxidative capacity under metabolic stress. [ujpronline.com], [biolongevitylabs.com]

Key References

1. Billon C, et al. A Synthetic ERR Agonist Alleviates Metabolic Syndrome. J Pharmacol Exp Ther. 2024;388(2):232–240. doi:10.1124/jpet.123.001733. [profiles.wustl.edu]
2. Eissa ME. SLU-PP-332 and Related ERRα Agonists: A Focused Minireview of Metabolic Regulation. Universal J Pharm Res. 2025;10(3):70–74. doi:10.22270/ujpr.v10i3.1355. [ujpronline.com]
3. FluxLabs Research Review. SLU-PP-332: The Exercise-Mimetic Compound Redefining Metabolic Research. 2023. PMID: 36988910. [fluxlabsusa.com]
4. Biolongevity Labs. SLU-PP-332 Peptide: ERR Agonist in Metabolic Research. 2025. [biolongevitylabs.com]
5. Tanida T. Molecular Dynamics of Estrogen-Related Receptors and Their Regulatory Proteins. Anat Sci Int. 2022;97:15–29. [link.springer.com]