KPV (10 Vial Box)

Compliance & Disclaimer

• For Research Use Only
• Not FDA or EMA approved for clinical application
• Evidence is limited to preclinical studies; safety and efficacy in humans remain unestablished.

KPV is a naturally occurring tripeptide fragment derived from α-melanocyte-stimulating hormone (α-MSH), recognized for its potent anti-inflammatory and immunomodulatory properties. Unlike the parent hormone, KPV retains these effects without influencing melanogenesis, making it a subject of interest in studies on inflammation resolution, epithelial repair, and immune regulation. [tydes.is], [oathpeptides.com]

Mechanistic Insights

• Melanocortin Receptor Interaction: KPV binds to MC1R and MC3R, G-protein-coupled receptors expressed on keratinocytes, macrophages, and epithelial cells. This interaction modulates intracellular signaling cascades, including NF-κB and MAPK, reducing transcription of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6. [tydes.is], [thepeptidecompany.co]
• PepT1 Transporter Uptake: In gastrointestinal models, KPV is absorbed via the hPepT1 transporter, enabling targeted delivery to inflamed mucosal tissues and enhancing epithelial barrier integrity. [lisatamati.com]
• Cytokine Modulation: KPV downregulates pro-inflammatory mediators while promoting anti-inflammatory cytokines like IL-10, supporting balanced immune responses without broad immunosuppression. [thepeptidecompany.co]
• Wound Healing Pathways: Research indicates KPV enhances keratinocyte migration, collagen deposition, and tight-junction stabilization, accelerating tissue repair and mucosal regeneration. [thepeptidecompany.co], [lisatamati.com]
• Antimicrobial Activity: Preliminary studies suggest KPV exhibits bacteriostatic effects against pathogens such as Staphylococcus aureus and Candida albicans, adding to its relevance in infection control research. [biotechpeptides.com]

Research Applications

• Inflammatory Disorders: Investigated in models of inflammatory bowel disease (IBD), KPV reduced disease activity, restored epithelial architecture, and decreased neutrophil infiltration. [corepeptides.com]
• Skin and Wound Healing: Topical KPV accelerated wound closure and reduced inflammatory markers in dermatologic models, making it a candidate for regenerative medicine studies. [thepeptidecompany.co]
• Nanoparticle Delivery Systems: Hyaluronic acid-coated KPV nanoparticles demonstrated enhanced mucosal healing and cytokine suppression in colitis models, highlighting advanced delivery strategies for research. [inpeptides.com], [lisatamati.com]
• Neuroinflammation: Emerging evidence suggests KPV may attenuate microglial activation and oxidative stress, positioning it for exploratory studies in neurodegenerative conditions. [lisatamati.com]

Key Peer-Reviewed & Scientific References

1. Brzoska T. et al. KPV Peptide and Its Role in Inflammation and Healing. Core Peptides, 2025. Link [tydes.is]
2. Attalla D. KPV: The Anti-Inflammatory Tripeptide and Cellular Repair Mechanism. The Peptide Company, 2025. Link [thepeptidecompany.co]
3. Keen V. Investigating KPV Peptide’s Anti-Inflammatory and Wound-Healing Properties. SocialX Research, 2025. Link [socialx.sa...tech-x.com]
4. Tamati L. The Peptide Series: KPV. Lisa Tamati Enterprises, 2025. Link [lisatamati.com]
5. Usman, Dr. Anti-Inflammation Studies and KPV Peptide. Biotech Peptides, 2022. Link [biotechpeptides.com]