Kisspeptin-10 (10 Vial Box)

Compliance & Disclaimer

• For Research Use Only
• Not FDA or EMA approved for clinical application
• Evidence is limited to preclinical studies; safety and efficacy in humans remain unestablished.

Kisspeptin-10 (KP-10) is a decapeptide fragment derived from the larger kisspeptin family encoded by the KISS1 gene, originally identified as a metastasis suppressor in melanoma and breast cancer cells. KP-10 represents the shortest biologically active sequence of kisspeptins and retains full receptor-binding capacity, making it a widely studied model for neuroendocrine and reproductive research. [biotechpeptides.com], [elevatedpeptides.com]

Mechanistic Insights

• Receptor Interaction: KP-10 acts as a high-affinity ligand for the KISS1 receptor (KISS1R/GPR54), a G-protein-coupled receptor expressed on GnRH neurons in the hypothalamus. Binding activates Gq/11 signaling, stimulating phospholipase C, mobilizing intracellular calcium, and activating protein kinase C (PKC) pathways. [peptideini...iative.com], [elevatedpeptides.com]
• GnRH Secretion: KP-10 triggers depolarization of GnRH neurons, leading to pulsatile release of gonadotropin-releasing hormone (GnRH) into the hypothalamic-pituitary portal system. This cascade stimulates luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion from the anterior pituitary, governing gonadal steroidogenesis and gametogenesis. [academic.oup.com], [frontiersin.org]
• Neuroendocrine Modulation: KP-10 is implicated in puberty onset, fertility regulation, and energy homeostasis, with emerging evidence of roles in mood regulation and neuroprotection. Studies also suggest KP-10 influences hypothalamic neuropeptides such as neuropeptide Y (NPY) and neurotransmitters including dopamine and serotonin, linking reproductive and metabolic pathways. [mdpi.com]

Research Applications

• Reproductive Axis Studies: KP-10 is considered a master regulator of the hypothalamic-pituitary-gonadal (HPG) axis, essential for understanding GnRH pulsatility, LH surge mechanisms, and pubertal development. [frontiersin.org]
• Infertility and IVF Research: Clinical trials have explored KP-10 as an ovulation trigger in IVF protocols, demonstrating effective induction of LH surges with reduced risk of ovarian hyperstimulation syndrome compared to hCG triggers. [regentherapy.com]
• Hypogonadotropic Hypogonadism Models: KP-10 administration has been shown to restore LH and testosterone secretion in men with GnRH deficiency, supporting its use in experimental endocrine therapies. [researchgate.net]
• Metabolic and Behavioral Studies: KP-10’s interaction with appetite-regulating neuropeptides and its potential orexigenic effects have been documented in hypothalamic cell models, suggesting a link between energy balance and reproductive signaling. [mdpi.com]

Key Peer-Reviewed References

1. Skorupskaite K. et al. The kisspeptin-GnRH pathway in human reproductive health and disease. Hum Reprod Update. 2014;20(4):485–500. DOI:10.1093/humupd/dmu009 [academic.oup.com]
2. Xie Q. et al. The Role of Kisspeptin in the Control of the Hypothalamic-Pituitary-Gonadal Axis and Reproduction. Front Endocrinol. 2022;13:925206. DOI:10.3389/fendo.2022.925206 [frontiersin.org]
3. Kotanidou S. et al. Kisspeptins Regulating Fertility: Potential Future Therapeutic Approach in Infertility Treatment. J Clin Med. 2025;14(10):3284. DOI:10.3390/jcm14103284 [mdpi.com]
4. Orlando G. et al. Effects of Kisspeptin-10 on Hypothalamic Neuropeptides and Neurotransmitters Involved in Appetite Control. Molecules. 2018;23(12):3071. DOI:10.3390/molecules23123071 [mdpi.com]
5. Seminara S.B. et al. Kisspeptin Overcomes GnRH Neuronal Suppression Secondary to Hyperprolactinemia in Humans. J Clin Endocrinol Metab. 2022;107:e3515–e3525. DOI:10.1210/clinem/dgac166 [researchgate.net]