GHRP-6

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BUY2GET1GHRP6-5

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BUY2GET1GHRP6-10

Compliance & Disclaimer

• For Research Use Only
• Not FDA or EMA approved for clinical application
• Evidence is limited to preclinical studies; safety and efficacy in humans remain unestablished.

GHRP-6 is a synthetic hexapeptide (sequence: His-D-Trp-Ala-Trp-D-Phe-Lys-NH₂) classified as a growth hormone secretagogue (GHS). It acts primarily as an agonist of the growth hormone secretagogue receptor type 1a (GHS-R1a), also known as the ghrelin receptor, which is expressed in the hypothalamus, pituitary, and peripheral tissues. [newsroompanama.com], [bluumpeptides.com]

Mechanistic Insights

• Receptor Binding and Signal Transduction:
  GHRP-6 binds to GHS-R1a, a G-protein-coupled receptor, initiating intracellular cascades involving phospholipase C activation, IP₃-mediated calcium mobilization, and protein kinase C (PKC) signaling. This leads to depolarization of pituitary somatotrophs and pulsatile growth hormone (GH) release. [newsroompanama.com], [uspeptideco.com]

• Hypothalamic-Pituitary Axis Modulation:
  Evidence suggests GHRP-6 acts at both pituitary and hypothalamic sites, stimulating growth hormone-releasing hormone (GHRH) secretion and inhibiting somatostatin, thereby amplifying GH pulsatility. Studies in hypothalamopituitary disconnection models confirm a central component to its mechanism. [academic.oup.com], [joe.biosci...tifica.com]

• Synergistic Action with GHRH:
  Co-administration of GHRP-6 and GHRH produces a supra-additive GH response, indicating complementary pathways for somatotroph stimulation. [academic.oup.com]

Research Applications

• Endocrine and Metabolic Studies:
  GHRP-6 is widely used to investigate GH/IGF-1 axis dynamics, energy homeostasis, and metabolic regulation. Research indicates potential roles in lipid metabolism, glucose regulation, and protein synthesis, making it relevant for studies on obesity, cachexia, and insulin sensitivity. [newsroompanama.com], [dailyillini.com]

• Tissue Repair and Regeneration:
  Preclinical data suggest GHRP-6 may enhance fibroblast activity, angiogenesis, and extracellular matrix remodeling, supporting its inclusion in wound-healing and regenerative biology research. [frontiersin.org], [dailyillini.com]

• Neuroendocrine Research:
  GHRP-6’s interaction with hypothalamic circuits and ghrelin pathways has prompted investigations into appetite regulation, sleep architecture, and stress response, positioning it as a candidate for neurobehavioral studies. [bluumpeptides.com], [oathpeptides.com]

Key Peer-Reviewed References

1. Berlanga-Acosta J. et al. Growth hormone releasing peptide-6 prevents doxorubicin-induced myocardial and extra-myocardial damages by activating prosurvival mechanisms. Front Pharmacol. 2024;15:1402138. DOI:10.3389/fphar.2024.1402138 [frontiersin.org]
2. Popovic V. et al. Blocked GHRP-6-induced GH secretion and absence of synergy with GHRH in hypothalamopituitary disconnection: evidence for hypothalamic action. J Clin Endocrinol Metab. 1995;80(3):942–947. DOI:10.1210/jcem.80.3.7883854 [academic.oup.com]
3. Fairhall K.M. et al. Central effects of GHRP-6 on GH release are inhibited by somatostatin. J Endocrinol. 1995;144(3):555–560. DOI:10.1677/joe.0.1440555 [joe.biosci...tifica.com]
4. Ghigo E. et al. Growth hormone-releasing peptides: mechanisms and clinical perspectives. Eur J Endocrinol. 1997;136(5):445–460. DOI:10.1530/eje.0.1360445 [academic.oup.com]
5. NordSci Research. GHRP-6 Growth Peptide: A Complete Overview and Research Guide. 2025. Link [nordscipeptides.com]