BPC-157, TB-500, KPV, GHK-Cu (KLOW Blend) (10 Vial Box)

Compliance & Disclaimer

• For Research Use Only
• Not FDA or EMA approved for clinical application
• Evidence is limited to preclinical studies; safety and efficacy in humans remain unestablished.

The KLOW blend combines four bioactive peptides—BPC-157, TB-500 (Thymosin Beta-4 fragment), KPV, and GHK-Cu—each with distinct but complementary mechanisms of action. This multi-peptide formulation is studied for its potential to enhance tissue repair, modulate inflammation, and support extracellular matrix remodeling through synergistic pathways. [thepeptidereport.com], [peptidesciences.com]

Mechanistic Insights

• BPC-157 (Body Protection Compound-157):
  A synthetic pentadecapeptide derived from gastric protein, BPC-157 promotes angiogenesis via VEGF and eNOS pathways, enhances fibroblast migration, and regulates nitric oxide signaling. It also activates FAK–paxillin and VEGFR2–Akt cascades, facilitating cell survival and organized collagen deposition in musculoskeletal and gastrointestinal models. [biolongevitylabs.com], [peptidesciences.com]

• TB-500 (Thymosin Beta-4 Fragment):
  TB-500 modulates actin polymerization, enabling rapid cell migration to injury sites. It upregulates VEGF, supports angiogenesis, and reduces fibrosis by limiting myofibroblast activity. These properties make TB-500 a key component in early wound-healing phases and tissue remodeling research. [peptidesciences.com], [biotechpeptides.com]

• KPV (Lys-Pro-Val):
  KPV is a tripeptide fragment of α-MSH with potent anti-inflammatory activity. It interacts with MC1R and MC3R receptors, downregulating NF-κB and pro-inflammatory cytokines (TNF-α, IL-1β, IL-6) while promoting IL-10 expression. KPV also aids epithelial barrier integrity and keratinocyte migration, supporting mucosal and dermal repair. [droracle.ai], [frontiersin.org]

• GHK-Cu (Glycyl-Histidyl-Lysine-Copper):
  GHK-Cu is a naturally occurring copper-binding tripeptide that stimulates collagen and elastin synthesis, enhances angiogenesis, and modulates gene expression linked to tissue repair. It also exhibits antioxidant and anti-inflammatory effects, reducing oxidative stress and promoting balanced extracellular matrix remodeling. [mdpi.com], [phoenixmedsinc.com]

Synergistic Potential

When combined, these peptides target multiple phases of the healing cascade:

• Inflammation Resolution: KPV suppresses inflammatory cytokines, creating a favorable environment for repair.
• Angiogenesis & Vascular Support: BPC-157 and TB-500 synergistically enhance blood vessel formation and oxygen delivery.
• Cell Migration & Matrix Remodeling: TB-500 accelerates cellular mobilization, while GHK-Cu and BPC-157 promote collagen deposition and structural integrity.
• Oxidative Stress Control: GHK-Cu mitigates free radical damage and supports antioxidant enzyme activity, complementing the anti-inflammatory effects of KPV. [peptidesciences.com], [allaboutpeptides.com]

Key Peer-Reviewed & Scientific References

1. Brzoska T. et al. KPV Peptide and Its Role in Inflammation and Healing. Core Peptides, 2025. Link [droracle.ai]
2. Pickart L., Margolina A. Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. Int J Mol Sci. 2018;19(7):1987. DOI:10.3390/ijms19071987 [mdpi.com]
3. Ky H. Le, MD. BPC-157 and TB-500 Peptides: Healing Mechanisms and Research Explained. BioLongevity Labs, 2025. Link [biolongevitylabs.com]
4. Hannah R. KLOW Peptide Blend: Exploring Synergistic Potential for Tissue Healing. Peptide Sciences, 2025. Link [peptidesciences.com]
5. All About Peptides Team. KLOW Peptide Blend: Benefits for Tissue Repair and Recovery. 2025. Link [allaboutpeptides.com]