BPC-157, TB-500, GHK-Cu (GLOW Blend) (10 Vial Box)

Compliance & Disclaimer

• For Research Use Only
• Not FDA or EMA approved for clinical application
• Evidence is limited to preclinical studies; safety and efficacy in humans remain unestablished.

The Glow Blend combines three bioactive peptides—BPC-157, TB-500 (Thymosin Beta-4 fragment), and GHK-Cu—each studied for distinct but complementary roles in tissue repair, angiogenesis, extracellular matrix remodeling, and oxidative stress modulation. This multi-peptide formulation is designed for research exploring synergistic mechanisms in regenerative biology and wound-healing pathways.

Mechanistic Insights

• BPC-157 (Body Protection Compound-157):
  A synthetic pentadecapeptide derived from gastric protein, BPC-157 has been shown in preclinical models to activate VEGFR2–Akt–eNOS signaling, promoting angiogenesis and microvascular integrity. It also influences FAK–paxillin pathways, enhancing fibroblast migration and collagen deposition, and modulates nitric oxide activity for vascular homeostasis.
  Citations: Sikiric et al., Pharmaceuticals 2025; McGuire et al., Curr Rev Musculoskelet Med 2025.

• TB-500 (Thymosin Beta-4 Fragment):
  TB-500 retains the actin-binding domain of thymosin beta-4, enabling G-actin sequestration and rapid actin polymerization during cell migration. This property supports lamellipodia formation, angiogenesis, and wound closure. TB-500 also upregulates VEGF and reduces fibrosis by modulating myofibroblast activity.
  Citations: Malinda et al., J Invest Dermatol 2004; Goldstein et al., Ann NY Acad Sci 2012.

• GHK-Cu (Glycyl-L-Histidyl-L-Lysine-Copper):
  GHK-Cu is a copper-binding tripeptide that regulates gene expression for collagen and elastin synthesis, stimulates angiogenesis, and exhibits antioxidant and anti-inflammatory properties. It also modulates matrix metalloproteinases (MMPs) and supports proteasome activity for cellular repair.
  Citations: Pickart & Margolina, Int J Mol Sci 2018; Phoenix Meds Inc., Clinical Review 2025.

Synergistic Potential

• Angiogenesis & Vascular Support: BPC-157 and TB-500 enhance microcirculation and endothelial repair, while GHK-Cu promotes capillary formation and oxygen delivery.
• Extracellular Matrix Remodeling: TB-500 accelerates cellular migration; GHK-Cu and BPC-157 stimulate collagen and elastin synthesis for structural integrity.
• Oxidative Stress & Inflammation Control: GHK-Cu mitigates free radical damage and inflammatory signaling, complementing BPC-157’s nitric oxide modulation.

Key Peer-Reviewed References

1. Sikiric P. et al. BPC 157 Therapy: Targeting Angiogenesis and Nitric Oxide’s Cytotoxic Actions. Pharmaceuticals. 2025;18(10):1450.
2. McGuire F.P. et al. Regeneration or Risk? A Narrative Review of BPC-157 for Musculoskeletal Healing. Curr Rev Musculoskelet Med. 2025.
3. Malinda K.M. et al. Thymosin β4 accelerates wound healing. J Invest Dermatol. 2004; DOI:10.1111/j.0022-202X.2004.23204.x.
4. Goldstein A.L. et al. Thymosin β4 promotes cardiac protection and repair. Ann NY Acad Sci. 2012; DOI:10.1111/j.1749-6632.2012.06762.x.
5. Pickart L., Margolina A. Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. Int J Mol Sci. 2018;19(7):1987. DOI:10.3390/ijms19071987.