SNAP-8 (10 Vial Box)

Compliance & Disclaimer

• For Research Use Only
• Not FDA or EMA approved for clinical application
• Evidence is limited to preclinical studies; safety and efficacy in humans remain unestablished.

SNAP-8 is a synthetic octapeptide designed as an extended analogue of acetyl hexapeptide-8 (Argireline), developed to mimic the N-terminal region of SNAP-25, a key component of the SNARE complex involved in neurotransmitter release at neuromuscular junctions. Structurally, SNAP-8 consists of eight amino acids (Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH₂) and is hypothesized to act by competitively inhibiting SNARE complex formation, thereby reducing vesicle fusion and acetylcholine release. [corepeptides.com], [canadapeptide.com] [corepeptides.com]

Mechanistically, SNAP-8 interferes with the assembly of the SNARE complex—comprising SNAP-25, syntaxin, and synaptobrevin—required for calcium-dependent exocytosis of neurotransmitters. By occupying binding sites on syntaxin and synaptobrevin, SNAP-8 may prevent SNAP-25 from forming a functional complex, reducing acetylcholine secretion and subsequent muscle contraction. This neuromodulatory effect has been studied primarily in the context of dynamic facial wrinkles, where repetitive muscle contractions contribute to skin creasing. [corepeptides.com], [peptideini...iative.com] [canadapeptide.com]

Preclinical and cosmetic research suggests SNAP-8 may influence skin biomechanics by reducing contraction intensity and potentially modulating extracellular matrix components such as collagen. While most published data derive from manufacturer-sponsored or small-scale studies, reported outcomes include reductions in wrinkle depth of up to ~34% after 28 days of topical application in controlled trials, though these findings often involve combination formulations rather than SNAP-8 monotherapy. [biotechpeptides.com] [bluumpeptides.com]

Beyond dermatology, SNAP-8’s structural similarity to SNAP-25 has prompted exploratory interest in neurobiological research, given its theoretical capacity to modulate synaptic vesicle fusion—a process implicated in neurological signaling and disorders. However, its primary application remains investigational within cosmetic science and peptide-based neuromodulation. [ourculturemag.com]

Key Peer-Reviewed & Scientific References

1. Nguyen T. et al. SNAP-8 Peptide: Research into the Neuronal Regulation of Skin Topography. Core Peptides, 2024. Link [corepeptides.com]
2. Trang T.M. et al. Sustainable Dynamic Wrinkle Efficacy: Non-Invasive Peptides as the Future of Botox Alternatives. Cosmetics, 2024;11(4):118. DOI:10.3390/cosmetics11040118 [mdpi.com]
3. Canada Peptide Review. SNAP-8: A Non-Invasive Anti-Wrinkle Peptide. 2025. Link [canadapeptide.com]
4. Biotech Peptides. Skin Research and the SNAP-8 Peptide. 2022. Link [biotechpeptides.com]
5. Bluumpeptides Technical Review. Snap-8 Research. 2025. Link [bluumpeptides.com]