Selank (10 Vial Box)

Compliance & Disclaimer

• For Research Use Only
• Not FDA or EMA approved for clinical application
• Evidence is limited to preclinical studies; safety and efficacy in humans remain unestablished.

Selank is a synthetic heptapeptide derived from tuftsin, an endogenous tetrapeptide involved in immune regulation. Structural modification with an additional Pro-Gly-Pro (PGP) tripeptide enhances Selank’s stability and ability to cross the blood–brain barrier, positioning it as a subject of interest in neuropharmacology and cognitive research. [corepeptides.com], [peptidesystems.com]

Mechanistic Insights

• GABAergic Modulation: Selank influences the expression of genes involved in GABA neurotransmission, acting as an allosteric modulator rather than directly binding to GABA-A receptors. This mechanism is associated with anxiolytic effects without sedation or dependence. [frontiersin.org], [polarispeptides.com]
• Monoamine Regulation: Research indicates Selank modulates serotonin, dopamine, and norepinephrine pathways, contributing to mood stabilization and stress resilience. [regentherapy.com], [muscleandbrawn.com]
• Neurotrophic Factor Upregulation: Selank has been shown to increase brain-derived neurotrophic factor (BDNF) and TrkB receptor expression, supporting synaptic plasticity and cognitive function. [peptidesystems.com]
• Enkephalinase Inhibition: Experimental data suggest Selank inhibits enkephalin-degrading enzymes, prolonging the activity of endogenous opioid peptides and potentially enhancing stress adaptation. [corepeptides.com]
• Immunomodulatory Effects: As a tuftsin analogue, Selank retains immune-regulating properties, influencing cytokine balance and gene expression linked to inflammatory responses. [peptides.org]

Research Applications

Preclinical and clinical studies have explored Selank in:

• Anxiety and Stress Models: Demonstrated anxiolytic effects comparable to benzodiazepines without sedative drawbacks. [frontiersin.org]
• Cognitive Enhancement: Animal studies report improved memory trace stability and learning under stress conditions, correlating with hippocampal gene expression changes. [biotechpeptides.com]
• Neuroprotection: Investigations suggest antioxidant and anti-inflammatory properties, positioning Selank as a candidate for research in neurodegenerative disorders. [tydes.is]

Key Peer-Reviewed References

1. Volkova A. et al. Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission. Front Pharmacol. 2016;7:31. DOI:10.3389/fphar.2016.00031 [frontiersin.org]
2. Zozulya A.A. et al. Selank Peptide: Potential Support for Neurotransmitters and Neurotrophins. Core Peptides, 2025. Link [corepeptides.com]
3. Anderson J. The Science Behind Selank. PeptideSystems, 2024. Link [peptidesystems.com]
4. Kolomin T. et al. Selank Peptide: Mechanism, Benefits, and Cognitive Research Insights. Tydes Insights, 2025. Link [tydes.is]
5. Filatova E. et al. Selank Peptide and the GABAergic System: Research Insights into Stress and Anxiety Regulation. Polaris Peptides, 2025. Link [polarispeptides.com]