PT-141 (10 Vial Box)

Compliance & Disclaimer

• For Research Use Only
• Not FDA or EMA approved for clinical application
• Evidence is limited to preclinical studies; safety and efficacy in humans remain unestablished.

PT-141 is a synthetic cyclic heptapeptide derived from Melanotan II, itself an analog of the endogenous melanocortin hormone α-melanocyte-stimulating hormone (α-MSH). It functions as a selective agonist of melanocortin receptors, primarily MC3R and MC4R, which are widely expressed in the central nervous system (CNS) and play key roles in neuroendocrine regulation, energy homeostasis, and sexual behavior. [biolongevitylabs.com], [biotechpeptides.com]

Mechanistic Insights

• Receptor Binding: PT-141 binds melanocortin receptors via a calcium-dependent mechanism, inducing conformational changes that activate cyclic adenosine monophosphate (cAMP) and protein kinase A (PKA) signaling cascades. [biolongevitylabs.com], [peptideini...iative.com]
• Biased Signaling: Research indicates PT-141 exhibits biased agonism, selectively activating certain downstream pathways while minimizing off-target effects, distinguishing it from other melanocortin analogs. [biolongevitylabs.com]
• Neuroendocrine Modulation: MC4R activation in hypothalamic and limbic regions influences dopaminergic and noradrenergic neurotransmission within the mesolimbic reward circuitry, which is implicated in sexual motivation and arousal. [championpeptides.com]
• Broader Physiological Roles: Beyond sexual function, PT-141’s receptor activity has been linked to research on energy expenditure, feeding behavior, and inflammatory signaling, suggesting potential applications in metabolic and neuroimmune studies. [biotechpeptides.com], [femimagazine.com]

Research Applications

Preclinical and clinical investigations have explored PT-141 in:

• Sexual Behavior Models: Demonstrated CNS-mediated effects on sexual desire and arousal without relying on peripheral vasodilation, differentiating it from PDE5 inhibitors. [peptideini...iative.com], [elementsarms.com]
• Neuropharmacology: Studies suggest modulation of neurotransmitter systems (dopamine, serotonin) and neuroplasticity, positioning PT-141 as a candidate for research into reward pathways and stress resilience. [femimagazine.com]
• Emerging Areas: Recent findings indicate potential roles in glioblastoma research via survivin suppression and in immunomodulatory processes through melanocortin receptor signaling. [championpeptides.com]

Key Peer-Reviewed & Scientific References

1. Ky H. Le, MD. PT-141 Peptide Research: From Neural Networks to Metabolism. BioLongevity Labs, 2025. Link [biolongevitylabs.com]
2. Bardhan et al. Comprehensive Analysis of Bremelanotide Clinical Development. Diseases, 2025. PMID:41002740 [championpeptides.com]
3. Usman, Dr. Bremelanotide and HSDD Related Research. Biotech Peptides, 2025. Link [biotechpeptides.com]
4. Peptide Initiative. How PT-141 Works – Brain Pathways & MC4R Activation. 2025. Link [peptideini...iative.com]
5. FEMI Magazine. PT-141 Peptide: Implications and Prospects in Research. 2025. Link [femimagazine.com]