GHK-Cu (10 Vial Box)

Compliance & Disclaimer

• For Research Use Only
• Not FDA or EMA approved for clinical application
• Evidence is limited to preclinical studies; safety and efficacy in humans remain unestablished.

GHK-Cu is a naturally occurring copper-binding tripeptide complex first identified in human plasma in 1973. It plays a critical role in tissue remodeling, wound healing, and cellular signaling. The peptide consists of three amino acids—glycine, histidine, and lysine—forming a high-affinity complex with copper ions, which is essential for its biological activity. [peptideini...iative.com], [mdpi.com]

Mechanistic Insights

• Gene Expression Modulation:
  GHK-Cu influences thousands of human genes, upregulating those involved in collagen synthesis, angiogenesis, and antioxidant defense, while downregulating genes linked to inflammation and fibrosis. This genomic modulation underpins its regenerative and protective effects across multiple tissue types. [mdpi.com], [europepmc.org]

• Extracellular Matrix Remodeling:
  GHK-Cu stimulates fibroblast activity and promotes synthesis of collagen, elastin, glycosaminoglycans, and decorin, essential for structural integrity and wound repair. It also regulates matrix metalloproteinases (MMPs) and their inhibitors (TIMPs), ensuring balanced tissue remodeling. [droracle.ai]

• Copper Delivery and Enzymatic Support:
  By chelating copper ions, GHK-Cu facilitates enzymatic reactions critical for antioxidant defense (superoxide dismutase) and angiogenesis, while preventing free copper-induced oxidative damage. [peptidesciences.com]

• Anti-Inflammatory and Antioxidant Effects:
  GHK-Cu reduces pro-inflammatory cytokines (TNF-α, IL-6) and oxidative stress markers, while enhancing IL-10 and antioxidant enzyme activity, creating a favorable environment for tissue regeneration. [newsroompanama.com]

Research Applications

• Wound Healing and Tissue Repair:
  Animal and human studies demonstrate accelerated epithelial repair, improved tensile strength, and enhanced angiogenesis in wound models treated with GHK-Cu. [phoenixmedsinc.com]

• Skin and Hair Regeneration:
  Clinical trials report measurable improvements in skin elasticity, reduction of fine lines, and increased hair follicle size, correlating with upregulation of extracellular matrix genes. [biolongevitylabs.com]

• Anti-Aging and Cellular Protection:
  GHK-Cu has been shown to restore youthful gene expression patterns, support DNA repair, and activate proteasome-mediated clearance of damaged proteins, positioning it as a candidate for aging and oxidative stress research. [mdpi.com], [europepmc.org]

Key Peer-Reviewed References

1. Pickart L., Margolina A. Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. Int J Mol Sci. 2018;19(7):1987. DOI:10.3390/ijms19071987 [mdpi.com]
2. Phoenix Meds Inc. GHK-Cu Clinical Studies: Evidence Insights on Collagen Production. 2025. Link [phoenixmedsinc.com]
3. Peptide Initiative. GHK-Cu Research Hub – Clinical Studies. 2025. Link [peptideini...iative.com]
4. Biolongevity Labs. GHK-Cu Peptide Science: Skin Aging and Hair Growth Research. 2025. Link [biolongevitylabs.com]
5. Peptide Sciences. GHK-Cu Research: Showing Promise With Inflammatory-Based Diseases. 2025. Link [peptidesciences.com]